Vitamin K is a fat-soluble vitamin essential for the functioning of several proteins involved in physiological processes. Naturally occurring forms are vitamin K1 (referred to as phylloquinone) and vitamin K2 (called menaquinones).
Vitamin K1, which is derived from green plants, is best known for the role it plays in blood clotting, while vitamin K2, derived primarily from fermented foods and animal products such as eggs, meat, and liver, is important to hormone production and utilization, as well as bone and heart health.
Vitamin K2 does not get the attention it deserves, and it’s highly likely you’re not getting enough in your diet. Although fat-soluble, the body stores very little and it’s rapidly depleted without the regular dietary intake.
Before discussing the numerous areas of your health where vitamin K2 has a significant impact, it’s first important to understand the different forms of the vitamin.
The Different Forms of Vitamin K2
Vitamin K2 is needed to activate the protein osteocalcin, which is found in your bones. Without vitamin K2, this and other vitamin K2-dependent proteins remain inactivated, and cannot perform their biological functions.
According to Leon Schurgers, a world-renowned researcher in vitamin K2, the difference between vitamins K1 and K2 was established in the Rotterdam Study, published in 2004, of which Schurgers was a co-author.
While the study focused on the difference between how K1 and K2 affect the heart (K1 does not affect at all), the researchers also looked at what types of foods supply each of the vitamins. In an interview, he said:
“I measured a variety of food items for vitamin K content … Vitamin K1 is highly available in green, leafy vegetables — spinach, kale, broccoli, and cabbage.
However, the absorption of vitamin K1 from food is extremely low. Only 10 percent of the vitamin K which is found in green leafy vegetables, is absorbed in your body … And there’s no variable or modification of the consumption that will significantly increase the absorption …”
K2, on the other hand, was only present in fermented foods. It’s produced by specific bacteria during the fermentation process.
Certain bacteria in your gut naturally produce vitamin K2 in your body as well. Interestingly, while the K1 in vegetables is poorly absorbed, virtually all of the K2 in fermented foods is readily available to your body. K2 can be further broken down into
• MK-4 (menaquinone-4), a short-chain form of vitamin K2 found in animal-based foods such as meats dairy and eggs. MK-4 also has a very short biological half-life — about 2.5 hours — making it a poor candidate as a dietary supplement.
That said, natural MK-4 from food is important for good health, as MK-4 plays a role in gene expression, turning some genes off and others on, and is therefore important for cancer prevention.1
• MK-7 (menaquinone-7), longer-chain forms found in fermented foods. There’s a variety of these long-chain forms, but the most common one is MK-7. This is the one you’ll want to look for in supplements, as this form is extracted from real food, specifically natto, a fermented soy product.
The MK-7, which forms in the fermentation process, has two major advantages. It stays in your body longer and has a longer half-life, which means you can take it just once a day in very convenient dosing.
Research has shown MK-7 helps prevent inflammation by inhibiting pro-inflammatory markers that can cause autoimmune diseases like rheumatoid arthritis.
While vitamin K1 has been found to “moderately reduce” the risk of bone fractures, MK-7 is more effective than vitamin K1 at reaching your bone.
In your bones, K2 is used to produce osteocalcin, improving metabolic and hormonal health and exercise performance.
Cardiovascular Protection and Cofactor for Vitamin D and Calcium
Calcium deposits in the arteries are responsible for atherosclerosis, hardening and narrowing of the arteries, slowly blocking blood flow. It’s a common cause of heart attacks, strokes, and peripheral vascular disease.
This vitamin is important in the activation of important proteins, such as matrix GLA-protein (MGP), found in your vascular system, and studies have demonstrated K2 inhibits arterial calcification and improves arterial flexibility, thereby reducing your risk of atherosclerosis.
One recent study proposed therapeutic supplementation with this vitamin could prevent or halt the progression of vascular calcification that may occur with excessive calcium intake, and other studies have demonstrated those eating the highest amount of vitamin K2 have the lowest risk of developing cardiovascular disease.
This vitamin also functions as an important cofactor for calcium and vitamin D. While calcium is important for strengthening bones and overall skeletal health, it only works when it gets to the right place.
This vitamin prevents calcium from being deposited along the walls of the blood vessels and directs it into the bone.
So, it’s important to remember that this vitamin and vitamin D (along with calcium and magnesium) have a synergistic relationship when it comes to your bone and heart health.
To maximize your benefits of oral vitamin D supplementation, it’s important to maintain optimal levels of vitamin K2. Studies indicate supplementing with both vitamins D3 and K2 offers greater cardiovascular health benefits than consuming either vitamin alone.
Vitamin K2 Plays a Role in Reducing Inflammation and Promoting Kidney Health
The inflammatory response is a crucial component in many chronic diseases and diseases of aging. Scientific evidence suggests both vitamin K1 and K2 have anti-inflammatory activity, in part by inhibiting nuclear factor kappa-B.30
For example, in one meta-analysis, researchers found evidence vitamin K has a protective role in chronic aging conditions, inflammation, and cardiovascular disease. Another study confirmed the role the vitamin K2 MK-7 form specifically has in the modulation of inflammatory biomarkers.
The researchers evaluated natural vitamin K2 for its potential to inhibit gene expression and production of pro-inflammatory markers in vitro, finding the MK-7 form inhibited gene expression in a dose-dependent manner.
How to Boost Your Intake of Vitamin K2 Naturally
If you decide to take a statin or use a vitamin D3 supplement, it is highly recommended you include a vitamin K2 supplement in the MK-7 form. Professor Cees Vermeer, one of the world’s top vitamin K2 researchers, recommends between 45 micrograms (mcg) and 185 mcg daily for adults.
Just remember that since this vitamin is fat-soluble, it’s best to take it with a small amount of fat to improve absorption. Consuming foods rich in vitamin K2 is your best bet.
MK-4 is found in animal foods such as free-range, organic eggs (particularly the yolk), dark chicken meat and goose liver. MK-7 is found in fermented foods such as natto, a type of fermented soy, and soft and hard cheeses such as Brie and Gouda.